Background
Hypoxic ischemic encephalopathy (HIE) stands as a significant cause of mortality in both adults and newborns. While previous investigations have predominantly concentrated on traumatic brain injuries in adults or neonates, there has been a recent increase in global research on neonatal HIE. This increase coincides with the growing use of high-throughput sequencing techniques, particularly the widespread adoption of multiomics methodologies. The aim of this study is to develop a risk prediction model and a comprehensive risk assessment system for HIE, integrating multi-omics.
By integrating comprehensive analyses of the genome, transcriptome, proteome, and metabolome of individuals afflicted with HIE, particularly neonates, we endeavor to delve into the genetic underpinnings of this condition, pinpointing mutated genes that heighten susceptibility. Additionally, we aim to elucidate variations in gene expression, highlighting pivotal genes and proteins implicated in the disease, alongside identifying metabolic alterations, thereby unveiling risk metabolites with significant impact.
Objectives of the project
Utilizing multi-omics data sourced from the UK Biobank, our aim is to unravel the potential molecular mechanisms of HIE, identifying genes, risk metabolites, and marker proteins that escalate susceptibility, thereby furnishing valuable insights for clinical diagnosis and treatment modalities. Through our research endeavors, we aspire to identify high-risk cohorts at early stages and implement timely interventions to mitigate the incidence and severity of HIE, ultimately ameliorating the quality of life for affected individuals and their families, with far-reaching implications for public health.
Expected Outcomes of the Project
This initiative will harness multi-omics data alongside environmental and phenotypic profiles of HIE to undertake meticulous investigations, endeavoring to unveil novel associations between genes and HIE. Our overarching goal is to facilitate early prevention and intervention strategies. Furthermore, by delving into the molecular intricacies of HIE, we endeavor to refine existing clinical approaches for prevention and treatmentata. we aim to discern the role of environmental factors, encompassing lifestyle, health conditions in adults, and specific birthing circumstances.
Additionally, the aim is to formulate clinical risk monitoring protocols and holistic strategies for prevention and treatment over a period of three years.