Previous studies have revealed that IBD patients have a higher risk of developing AAE, and the underlying mechanisms contributing to this risk could involve prolonged exposure to high serum levels of low-density lipoprotein cholesterol, adipokines, and inflammatory and pro-inflammatory cytokines. The current research project aims to identify the specific metabolomic, proteomic and genomic biomarkers, pre-disease cardiac imaging and exercise physiology characteristics associated with AAE risk using UK Biobank data to develop personalized clinical management plans for IBD patients. The findings of this study could significantly impact public health by improving the management of IBD patients and reducing their risk of developing CVD. By utilizing -omics approaches, this research could aid in developing effective diagnostic, prognostic, and therapeutic strategies for IBD patients and ultimately enhance their overall health outcomes. Overall, this research project is of great public interest and could significantly improve the management and outcomes of IBD patients.
