Aim:
Our project is committed to investigate the causal link between multi-dimensional lifestyle factors (including physical activity, diet, smoking, alcohol consumption, and sleep patterns) and cancer risk and prognosis, and to evaluate the efficacy of lifestyle interventions on the incidence and prognosis of cancers. The aim of the research is to explore and precisely identify the key lifestyle determinants affecting cancer incidence and prognosis.
Scientific rationale:
Our previous finding showed that sleep pattern is highly related with occurrence of cancer and mediated by blood metabolites especially the concentration of branched chain amino acid (which was supplied by UK BioBank). Therefore our research will utilize the high-quality and large-scale dataset from the UK Biobank to investigate a broad spectrum of factors impacting cancer development, with the goal of precisely identifying the key determinants involved in the occurrence and development of cancer risk and prognosis. By integrating plasma metabolomics profiling accompany with epidemiological data, this work aims to develop evidence-based lifestyle intervention frameworks for cancer prevention. We will further utilize mouse model to elucidate the underlying molecular and cellular mechanisms. The results of our findings will be submitted to high-impact academic journals. Our conclusion will provide life guidance for healthy people and cancer patients, and reduce the incidence and mortality of cancer.
Research duration:
The project is expected to last for 36 months.
Public health impact:
The results of our study will help identify risk factors, reduce the incidence of cancer in high-risk groups and improve the standards of diagnosis and treatment. Through analysis of risk and prognostic factors, our study will contribute to developing more effective cancer patient management strategies in clinical practice.
