Research question(s)
This research is dedicated to deepening our understanding of Gallbladder and Pancreatic Diseases, including the following diseases!
1.Benign gallbladder diseases (cholecystitis, gallstones, gallbladder polyps)
2.Gallbladder cancer and bile duct cancer
3.Common bile duct stones
4.Complications of gallbladder loss (after cholecystectomy)
5.Acute pancreatitis,chronic pancreatitis,recurrent acute pancreatitis,autoimmune pancreatitis;
6.Pancreatic cancer;
7.Acute pancreatitis-related splanchnic vein thrombosis
Research objectives(s)
Develop Comprehensive Risk Prediction Models: Create models incorporating genetic, omics, clinical, and environmental data to identify individuals at higher risk of these conditions.
Identify Targets for Interventions: Discover potential biomarkers and pathways for new treatments or preventive strategies based on genetic and omics findings.
Scientific rationale for the research
In recent decades, the etiology of various benign diseases of the gallbladder and biliary system has not been fully understood, and the incidence rate and mortality of malignant tumors of the biliary and pancreatic system are on the rise globally. In addition, patients with various types of pancreatitis often experience recurrent attacks even after being cured of acute attacks, causing great pain to patients and their families, posing severe challenges to doctors, and leading to many complications,such as splanchnic vein thrombosis,which is a rare complication of acute pancreatitis. Due to the lack of previous research, the purpose of this study was to analyze the medical records of acute pancreatitis-related splanchnic vein thrombosis and pancreatic portal hypertension to explore its risk factors, effective diagnosis and the effects of treatments including anticoagulation.Our research will utilize the resources of the UK BioBank to address the aforementioned unresolved issues and protect public health.
