aims: The aim of this study was to investigate the relevance of lifestyle to the development of cardiovascular disease and cancer in NAFLD in the UK population based on non-alcoholic fatty liver disease (NAFLD) status and to give clinical guidance.
scientific rationale: NAFLD is one of the most common chronic liver diseases, which affects up to one-third of the world’s adults, is an independent risk factor for increased cardiovascular mortality. Considering that cardiovascular disease is the most common cause of death in the NAFLD population, strategies to reduce cardiovascular mortality in the NAFLD population are urgently needed. In addition, the risk of extrahepatic cancer may have been underestimated so far. NAFLD may be a more important intermediate biomarker of cancer risk. Given the lack of FDA-approved drug therapies, it is important to clarify the risk factors for NAFLD and give appropriate lifestyle guidance. However, there are no guidelines for specific lifestyle guidance for patients with NAFLD.
public health impact: Our work provided a better understanding of potential risk factors for the occurrence and development of NAFLD. It helps to reduce the medical and economic burden on society.
