Since the time of Darwin, how selection shapes human evolution has been an interesting and important topic because of its potential clinical values and social impacts. However, due to the lack of population genomic data, many past studies utilized phenotypic data to infer selections on human traits. Alternatively, comparative studies inferred selections in the human lineage by comparing limited genomic data from humans with those from other apes. Nonetheless, these studies cannot directly detect contemporary selections acting on humans. With large-scale whole-genome sequencing data and phenotypic data in the UK Biobank, we aim to link selection on human phenotypes with the underlying genetic architecture. Our research objectives include: (1) exploring how sexual antagonism in humans is maintained by selection, with an emphasis on the mitochondrial genome; (2) quantifying the similarity between phenotypic correlation and genetic correlation and testing the role of selection in creating this similarity; (3) quantifying the effects of recent environmental and societal changes on selection.
