This study is focused on understanding how inflammation works in different rheumatic diseases, including inflammatory and autoimmune diseases. Even though inflammation is common in these diseases, the specific biological pathways and mechanisms behind it can vary greatly from one disease to another and even among patients with the same disease. The research aims to categorize rheumatic diseases and identify specific patient groups by examining the pattern of somatic mutations. These mutations occur in the DNA of stem cells that produce blood cells, leading to the growth of certain cell lines that can affect how the body’s immune system works and how inflammation develops. To do this, the study will analyze genetic data and other types of information from biomedical databases and public datasets related to genetics and health.
