Last updated:
ID:
8786
Start date:
2 February 2015
Project status:
Closed
Principal investigator:
Professor Neil Davies
Lead institution:
University of Bristol, Great Britain

Research question: what are the causal effects of education on morbidity and cause specific mortality?

Outcomes: all-cause and cause-specific mortality, coronary heart disease, lung cancer and income.

Exposure: education.

Synopsis: On average people with more years of education live longer and are healthier. We do not know whether this is because more educated people are less likely to engage in risky behaviours such as smoking, or if there are other differences, such as cognition or social class, which cause some people to be both healthier and more educated.

We will address this hypothesis using statistical techniques for differentiating causation and correlation. Low education is a major risk factor for a wide range of diseases.

We will use data from the UK biobank to improve our understanding of how individuals’ educational choices early in life affect their long term health outcomes.

Ultimately, knowledge from this project will help policy makers and practitioners mitigate these differences. Furthermore, our results will provide evidence about the consequences of the recent decisions to further increase the minimum school leaving age to 18 and to widen access to higher education. We will use data on all individuals from biobank with information on date and country of birth and age at which they left full time education.

We will investigate differences in health outcomes by duration of education. We will present adjusted results adjusted for known confounders (such as income, cognition).

We will use the raising of the school leaving age in 1972 and genetic variants known to associate with education as a natural experiments (instrumental variable) for educational achievement to identify the causal effects of education. We will use participants born outside the UK as a negative control population to provide further validation of our methods (1). We do not expect the changing of the school leaving age to affect the educational attainment of individuals born outside of the UK.

Related publications

Author(s)
Neil Martin Davies, David Hill, Emma L Anderson, Eleanor Sanderson, Ian J Deary, George Davey Smith
Journal
eLife
Author(s)
Robyn E Wootton, Rebecca B Lawn, Louise A C Millard, Neil M Davies, Amy E Taylor, Marcus R Munafò, Nicholas J Timpson, Oliver S…
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The BMJ
  • heart and blood vessels
Author(s)
Wes Spiller, Fernando Pires Hartwig, Eleanor Sanderson, George Davey Smith, Jack Bowden
Journal
PLOS ONE
Author(s)
Laurence J. Howe, David M. Evans, Gibran Hemani, George Davey Smith, Neil M. Davies
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PLOS Genetics
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Rachael A. Hughes, Neil M. Davies, George Davey Smith, Kate Tilling
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Epidemiology
Author(s)
Matthew J Tudball, Rachael A Hughes, Kate Tilling, Jack Bowden, Qingyuan Zhao
Journal
Biometrika
Author(s)
Neil M. Davies, Matt Dickson, George Davey Smith, Gerard J. van den Berg, Frank Windmeijer
Journal
Nature Human Behaviour
Author(s)
Tom G Richardson, Philip C Haycock, Jie Zheng, Nicholas J Timpson, Tom R Gaunt, George Davey Smith, Caroline L Relton, Gibran Hemani
Journal
Human Molecular Genetics
  • genetic diseases
Author(s)
Laurence J Howe, Humaira Rasheed, Paul R Jones, Dorret I Boomsma, David M Evans, Alexandros Giannelis, Caroline Hayward, John L Hopper, Amanda Hughes, Hannu…
Journal
International Journal of Epidemiology
Author(s)
Edward Mountjoy, Neil M Davies, Denis Plotnikov, George Davey Smith, Santiago Rodriguez, Cathy E Williams, Jeremy A Guggenheim, Denize Atan
Journal
The BMJ
  • eye
Author(s)
Tom G Richardson, Rebecca C Richmond, Teri-Louise North, Gibran Hemani, George Davey Smith, Gemma C Sharp, Caroline L Relton
Journal
International Journal of Epidemiology
  • reproductive and urinary health
Author(s)
Tom G Richardson, Sean Harrison, Gibran Hemani, George Davey Smith
Journal
eLife
  • mental health
Author(s)
Eleanor Sanderson, George Davey Smith, Frank Windmeijer, Jack Bowden
Journal
International Journal of Epidemiology
Author(s)
Simon Haworth, Ruth Mitchell, Laura Corbin, Kaitlin H. Wade, Tom Dudding, Ashley Budu-Aggrey, David Carslake, Gibran Hemani, Lavinia Paternoster, George Davey Smith, Neil Davies,…
Journal
Nature Communications
Author(s)
Ben Brumpton, Eleanor Sanderson, Karl Heilbron, Fernando Pires Hartwig, Sean Harrison, Gunnhild Åberge Vie, Yoonsu Cho, Laura D. Howe, Amanda Hughes, Dorret I. Boomsma,…
Journal
Nature Communications
Author(s)
Gareth J. Griffith, Tim T. Morris, Matthew J. Tudball, Annie Herbert, Giulia Mancano, Lindsey Pike, Gemma C. Sharp, Jonathan Sterne, Tom M. Palmer, George…
Journal
Nature Communications
  • infections
Author(s)
Wes Spiller, David Slichter, Jack Bowden, George Davey Smith
Journal
International Journal of Epidemiology
  • nutrition and metabolism
Author(s)
Laurence J Howe, Matthew Tudball, George Davey Smith, Neil M Davies
Journal
International Journal of Epidemiology
  • nutrition and metabolism
Author(s)
Eleanor Sanderson, George Davey Smith, Jack Bowden, Marcus R. Munafò
Journal
Nature Communications
Author(s)
Costin Leu, Tom G. Richardson, Tobias Kaufmann, Dennis van der Meer, Ole A. Andreassen, Lars T. Westlye, Robyn M. Busch, George Davey Smith, Dennis…
Journal
PLOS ONE
  • brain

All publications