Last updated:
ID:
44448
Start date:
7 March 2019
Project status:
Current
Principal investigator:
Professor Claudia Langenberg
Lead institution:
University of Cambridge, Great Britain

We will use the full data set of 500,000 participants to understand the contribution of our genes, lifestyle and environmental risk factors on cardiometabolic disease, with a focus on type 2 diabetes. This will help improve our understanding of the underlying biology to improve public health.

Related publications

Causal associations between cardiorespiratory fitness and type 2 diabetes
Author(s)
Lina Cai, Tomas Gonzales, Eleanor Wheeler, Nicola D. Kerrison, Felix R. Day, Claudia Langenberg, John R. B. Perry, Soren Brage, Nicholas J. Wareham
Journal
Nature Communications
  • nutrition and metabolism
The influence of rare variants in circulating metabolic biomarkers
Author(s)
Fernando Riveros-Mckay, Clare Oliver-Williams, Savita Karthikeyan, Klaudia Walter, Kousik Kundu, Willem H. Ouwehand, David Roberts, Emanuele Di Angelantonio, Nicole Soranzo, John Danesh, Eleanor Wheeler,…
Journal
PLOS Genetics
  • heart and blood vessels
ADRA2A and IRX1 are putative risk genes for Raynaud’s phenomenon
Author(s)
Sylvia Hartmann, Summaira Yasmeen, Benjamin M. Jacobs, Spiros Denaxas, Munir Pirmohamed, Eric R. Gamazon, Mark J. Caulfield, Harry Hemingway, Maik Pietzner, Claudia Langenberg
Journal
Nature Communications
  • heart and blood vessels
A cross-platform approach identifies genetic regulators of human metabolism and health
Author(s)
Luca A. Lotta, Maik Pietzner, Isobel D. Stewart, Laura B. L. Wittemans, Chen Li, Roberto Bonelli, Johannes Raffler, Emma K. Biggs, Clare Oliver-Williams, Victoria…
Journal
Nature Genetics
  • eye
  • genetic diseases
  • nutrition and metabolism
Genetically Predicted Glucose-Dependent Insulinotropic Polypeptide (GIP) Levels and Cardiovascular Disease Risk Are Driven by Distinct Causal Variants in the GIPR Region
Author(s)
Nicholas Bowker, Robert Hansford, Stephen Burgess, Christopher N. Foley, Victoria P.W. Auyeung, A. Mesut Erzurumluoglu, Isobel D. Stewart, Eleanor Wheeler, Maik Pietzner, Fiona Gribble,…
Journal
Diabetes
  • heart and blood vessels
  • nutrition and metabolism
Rare and common genetic determinants of metabolic individuality and their effects on human health
Author(s)
Praveen Surendran, Isobel D. Stewart, Victoria P. W. Au Yeung, Maik Pietzner, Johannes Raffler, Maria A. Wörheide, Chen Li, Rebecca F. Smith, Laura B.…
Journal
Nature Medicine
  • genetic diseases
Quantifying the Relationship Between Physical Activity Energy Expenditure and Incident Type 2 Diabetes: A Prospective Cohort Study of Device-Measured Activity in 90,096 Adults
Author(s)
Tessa Strain, Paddy C. Dempsey, Katrien Wijndaele, Stephen J. Sharp, Nicola Kerrison, Tomas I. Gonzales, Chunxiao Li, Eleanor Wheeler, Claudia Langenberg, Søren Brage, Nick…
Journal
Diabetes Care
  • nutrition and metabolism
Complex patterns of multimorbidity associated with severe COVID-19 and long COVID
Author(s)
Maik Pietzner, Spiros Denaxas, Summaira Yasmeen, Maria A. Ulmer, Tomoko Nakanishi, Matthias Arnold, Gabi Kastenmüller, Harry Hemingway, Claudia Langenberg
Journal
Communications Medicine
Identification of Rare Loss-of-Function Genetic Variation Regulating Body Fat Distribution
Author(s)
Mine Koprulu, Yajie Zhao, Eleanor Wheeler, Liang Dong, Nuno Rocha, Chen Li, John D Griffin, Satish Patel, Marcel Van de Streek, Craig A Glastonbury,…
Journal
The Journal of Clinical Endocrinology & Metabolism
  • nutrition and metabolism
Mapping the proteo-genomic convergence of human diseases
Author(s)
Maik Pietzner, Eleanor Wheeler, Julia Carrasco-Zanini, Adrian Cortes, Mine Koprulu, Maria A Wörheide, Erin Oerton, James Cook, Isobel D Stewart, Nicola D Kerrison, Jian'an…
Journal
Science
  • gut health
  • infections
  • skin and connective tissue
MC3R links nutritional state to childhood growth and the timing of puberty
Author(s)
B. Y. H. Lam, A. Williamson, S. Finer, F. R. Day, J. A. Tadross, A. Gonçalves Soares, K. Wade, P. Sweeney, M. N. Bedenbaugh,…
Journal
Nature
The association between circulating 25-hydroxyvitamin D metabolites and type 2 diabetes in European populations: A meta-analysis and Mendelian randomisation analysis
Author(s)
Ju-Sheng Zheng, Jian'an Luan, Eleni Sofianopoulou, Stephen J. Sharp, Felix R. Day, Fumiaki Imamura, Thomas E. Gundersen, Luca A. Lotta, Ivonne Sluijs, Isobel D.…
Journal
PLOS Medicine
  • nutrition and metabolism
Meta-analysis investigating the role of interleukin-6 mediated inflammation in type 2 diabetes
Author(s)
Nicholas Bowker, Rupal L. Shah, Stephen J. Sharp, Jian'an Luan, Isobel D. Stewart, Eleanor Wheeler, Manuel A.R. Ferreira, Aris Baras, Nicholas J. Wareham, Claudia…
Journal
EBioMedicine
  • nutrition and metabolism
Plasma Vitamin C and Type 2 Diabetes: Genome-Wide Association Study and Mendelian Randomization Analysis in European Populations
Author(s)
Ju-Sheng Zheng, Jian'an Luan, Eleni Sofianopoulou, Fumiaki Imamura, Isobel D. Stewart, Felix R. Day, Maik Pietzner, Eleanor Wheeler, Luca A. Lotta, Thomas E. Gundersen,…
Journal
Diabetes Care
  • nutrition and metabolism
Genetic basis of early onset and progression of type 2 diabetes in South Asians
Author(s)
Sam Hodgson, Alice Williamson, Margherita Bigossi, Daniel Stow, Benjamin M. Jacobs, Miriam Samuel, Joseph Gafton, Julia Zöllner, Marie Spreckley, Claudia Langenberg, David A. van…
Journal
Nature Medicine
Sex differences in the genetic regulation of the human plasma proteome
Author(s)
Mine Koprulu, Eleanor Wheeler, Nicola D. Kerrison, Spiros Denaxas, Julia Carrasco-Zanini, Chloe M. Orkin, Harry Hemingway, Nicholas J. Wareham, Maik Pietzner, Claudia Langenberg
Journal
Nature Communications
Using human genetics to understand the disease impacts of testosterone in men and women
Author(s)
Katherine S Ruth, Felix R Day, Jessica Tyrrell, Deborah J Thompson, Andrew R Wood, Anubha Mahajan, Robin N Beaumont, Laura Wittemans, Susan Martin, Alexander…
Journal
Nature Medicine
  • cancer and other tissue growths
  • nutrition and metabolism

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