This project aims to:(i) based on general data and genetic data, study the interaction of abnormal glucose and lipid metabolism as well as immune regulation on the occurrence, development and mortality risk of chronic non-communicable diseases (NCDs); (ii) based on general data and omics data, construct a new model for the early screening and diagnosis of chronic non-communicable diseases; (iii) based on omics data and corresponding genetic data, further explore the potential biological pathways and mechanisms of chronic non-communicable diseases.
The outcomes of this project will enhance our understanding of the mechanisms by which abnormal glucose and lipid metabolism and immune regulation lead to the risk of chronic non-communicable diseases in the future. In addition, this project can also identify key risk factors for chronic non-communicable diseases, establish an early warning model, realize the early diagnosis and early warning of chronic non-communicable diseases, and reduce the incidence of chronic non-communicable diseases.
Abnormal glucose and lipid metabolism (e.g., hyperglycemia, hyperlipidemia, insulin resistance) and immune disorders are key driving factors for the occurrence and progression of NCDs. Epidemiological studies have shown that long-term hyperlipidemia is a major risk factor for exacerbating inflammation and initiating the pathological process of atherosclerosis; abnormally activated immune cells and reduced insulin secretion are significantly associated with the progression of “insulin resistance” to “Type 2 diabetes”. However, the interactive effects of these factors and their combined impact on NCDs have not been fully elucidated, especially the complex mechanisms under genetic backgrounds and long-term exposure scenarios.
