Major non-communicable diseases (NCDs) have become a major global health threat. In recent years, research has shown that various factors such as lifestyle, social factors, psychological status, environment and genetics are closely related to the occurrence and development of NCDs. The COVID-19 pandemic has further complicated this landscape, with emerging evidence suggesting that COVID-19 and post-COVID-19 condition may have long-term health implications, including an increased risk of developing NCDs. Furthermore, plasma biomarkers may play a mediating role between these factors and NCDs. Despite the growing body of research on NCDs, there is a significant gap in understanding the integrated effects of these factors on NCDs, and the mediating role of plasma biomarkers. What is the impact of lifestyle, social factors, psychological status, COVID-19 condition, environmental and genetic factors on the incidence and progression of NCDs? What is the mediating role of plasma biomarkers in the relationship between lifestyle, social factors, psychological status, COVID-19 condition, environmental and genetic factors and NCDs? This research aims to fill this gap by conducting a comprehensive study that integrates multiple dimensions of risk factors and biological markers.
We will use multiple analysis methods such as polygenic score, regression analysis, mediation analysis, genome-wide association analysis, Mendelian randomization analysis, and machine learning algorithm to comprehensively analyze the interaction of genetic risk and other risk factors, including lifestyle social factors, psychological status, COVID-19 condition and environmental factors, on the risk of major NCDs, as well as the mediating role of plasma biomarkers. The research result is expected to reveal new potential pathways and mechanisms of the occurrence and development of NCDs, and promote personalized and precise prevention, treatment and prognosis of NCDs.
