Obesity is a growing public health problem and a well-established risk factor for chronic disease, including cardiovascular and metabolic disease, cognitive impairment, the metabolic dysregulation associated with obesity is similar to that observed in normal aging, and substantial evidence suggests the potential of obesity to accelerate aging, obesity is associated with accelerated aging of multiple organs. Obesity’s onset and progression is influenced by a range of factors, including environmental, lifestyle, genetic, psychological factors, However, the extent to which these factors contribute to obesity and its comorbidities remains to be investigated.
This research project aims to understand how different factors, such as our environment, genetics, lifestyle, and mental health, contribute to the occurrence and prognosis of obesity and obesity-related chronic diseases. We will integrate transcriptomics and imaging analyses to identify multiple biomarkers of obesity risk with high predictive accuracy and to establish an early warning model for “high-risk” obesity. Additionally, we’ll explore how obesity affects the aging of organs, especially the brain, and how our genes might be involved in this process. The project is expected to be completed within 36 months.
Understanding these relationships will help us develop better ways to prevent and manage obesity and its complications. Ultimately, this research could lead to improvements in public health and reduce the burden of obesity-related chronic diseases.
