Research Questions:
1.What are the key genetic, environmental, clinical, biochemical, and lifestyle factors influencing the development and progression of both non-communicable diseases (e.g., cardiovascular diseases, diabetes mellitus, pulmonary embolism, pulmonary hypertension, asthma, chronic obstructive pulmonary disease, obstructive sleep apnea-hypopnea syndrome) and communicable diseases (e.g., infectious diseases, COVID-19, sepsis)?
2.How do these determinants interact with one another, and what are their underlying mechanisms and combined effects on disease risk and progression?
3.Can identifying these factors yield novel insights into personalized prevention, disease severity assessment, and therapeutic strategies?
Objective:
1.Identify and analyze the genetic, environmental, clinical characteristics, laboratory biomarkers, imaging, and lifestyle determinants of non-communicable diseases (NCDs).
2.Investigate the interactions among these factors and their integrated impact on disease risk, progression, and comorbidities.
3.Provide actionable insights for personalized therapeutics, early diagnosis, prevention, and prognostic interventions.
Scientific Rationale:
The escalating global burden of non-communicable diseases underscores the urgent need to decipher their multifactorial etiology. By examining the interplay of genetic susceptibility, environmental exposures, lifestyle factors, and clinical data, this study seeks to unravel the mechanistic underpinnings of disease pathogenesis. Such insights will advance precision medicine through data-driven, tailored interventions to mitigate health disparities and improve clinical outcomes. Additionally, the findings may catalyze the discovery of novel therapeutic targets and next-generation diagnostic tools, further illuminating the pathophysiological pathways of NCDs.
