Research question
Digestive system tumors is the most common malignant tumor in our country. According to the 2021 Global Burden of Disease Study, gastrointestinal malignancies occur in 5.26 million people and cause 3.7 million deaths. From 2000 to 2021, the age-standardized incidence rate (ASIR) of gastric cancer and liver cancer has increased, and statistics show that gastrointestinal tumors account for more than 25% of the incidence of all tumors, and gastrointestinal tumors show a trend of gradually high prevalence in China.The occurrence of gastrointestinal neoplasms is related to many factors .Some studies have shown ,both genetics and lifestyle habits contribute to digestive system tumors, but the extent to which lifestyle changes genetic susceptibility to digestive system tumors remains unclear.
Objective
To address this gap, the present undertaking aims to employ an integrated approach, leveraging the wealth of genetics, metabolomics, proteomics, lifestyle factors and comprehensive epidemiological data.Through multi-dimensional analysis, we aimed to investigate whether lifestyle habits and genetic factors co-contribute to the development of digestive system tumors , and to what extent lifestyle habits alter genetic susceptibility.
Scientific Rationale
Existing studies indicate that poor lifestyle habits (e.g., high salt intake, nitrate-rich foods, smoking, alcohol consumption, and sleep deprivation) and genetic mutations contribute to digestive system tumors. However, the extent to which lifestyle habits modify genetic susceptibility remains unclear. To address this, we will integrate genetics, metabolomics, proteomics, lifestyle factors, and medical data to investigate how lifestyle and genetic factors jointly influence gastric cancer development. By analyzing multi-omics and epidemiological data, we aim to uncover the complex interplay between lifestyle habits and genetic mutations in digestive system tumors.
