Congestive heart failure affects about 5 million patients in the US alone, and our undrestanding of its genetic basis is incomplete. Here, we set out to identify rare genetic changes and common genetic changes that either increase or decrease heart failure risk. We do this by perfomring various associated analyses using UKBiobank data combiined with Allofus and MESA cohort datasets. We also seek to identify the genetic explanations for why some individuals with heart failure-associated variants do not develop heart failure, or do so with variable severity. This project will continue for 3 years, and has the potential to reveal new genetic causes of heart failure, as well as insights into its pathogenesis and new treatment candidates.
