Last updated:
Author(s):
Chen Wang, Marco Masala, Edoardo Fiorillo, Marcella Devoto, Francesco Cucca, Iuliana Ionita-Laza
Publish date:
21 July 2025
Journal:
Genetics
PubMed ID:
40690556

Abstract

Subtle population structure remains a significant concern in genome-wide association studies. Using human height as an example, we show how quantile regression, a natural extension of linear regression, can better correct for subtle population structure due to its inherent ability to adjust for quantile-specific effects of covariates such as principal components. We utilize data from the UK Biobank and the SardiNIA/ProgeNIA project for demonstration.

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