Abstract
Our published paper investigates strategies for reducing the risk of cardiovascular disease, and asks whether the addition of genetic information improves the performance of established tools for calculating disease risk. The paper has a particular focus on non-European ethnicities and ancestries.
Research highlights
– A new integrated risk tool combines clinical and polygenic risk scores
– Prediction is significantly enhanced in multiple ethnicities and ancestries
– Ethnicities include Black and White, ancestries include African and European
– This is the first positive cross-ethnicity cross-ancestry validation of such a tool