@article{Huang2019,
title = {A Genome-Wide Association Study for Susceptibility to Visual Experience-Induced Myopia},
author = {Y Huang and CS Kee and PM Hocking and C Williams and SP Yip and JA Guggenheim and UK Biobank Eye and Vision Consortium and The CREAM Consortium.},
url = {https://www.ncbi.nlm.nih.gov/pubmed/30721303},
year = {2019},
date = {2019-01-01},
journal = {Investigative Ophtalmology and Visual Science},
abstract = {Purpose:
The rapid rise in prevalence over recent decades and high heritability of myopia suggest a role for gene-environment (G × E) interactions in myopia susceptibility. Few such G × E interactions have been discovered to date. We aimed to test the hypothesis that genetic analysis of susceptibility to visual experience-induced myopia in an animal model would identify novel G × E interaction loci.

Methods:
Chicks aged 7 days (n = 987) were monocularly deprived of form vision for 4 days. A genome-wide association study (GWAS) was carried out in the 20% of chicks most susceptible and least susceptible to form deprivation (n = 380). There were 304,963 genetic markers tested for association with the degree of induced axial elongation in treated versus control eyes (A-scan ultrasonography). A GWAS candidate region was examined in the following three human cohorts: CREAM consortium (n = 44,192), UK Biobank (n = 95,505), and Avon Longitudinal Study of Parents and Children (ALSPAC; n = 4989).

Results:
A locus encompassing the genes PIK3CG and PRKAR2B was genome-wide significantly associated with myopia susceptibility in chicks (lead variant rs317386235, P = 9.54e-08). In CREAM and UK Biobank GWAS datasets, PIK3CG and PRKAR2B were enriched for strongly-associated markers (meta-analysis lead variant rs117909394, P = 1.7e-07). In ALSPAC participants, rs117909394 had an age-dependent association with refractive error (-0.22 diopters [D] change over 8 years, P = 5.2e-04) and nearby variant rs17153745 showed evidence of a G × E interaction with time spent reading (effect size -0.23 D, P = 0.022).

Conclusions:
This work identified the PIK3CG-PRKAR2B locus as a mediator of susceptibility to visually induced myopia in chicks and suggests a role for this locus in conferring susceptibility to myopia in human cohorts.},
keywords = {17351, genetics, myopia, vision},
pubstate = {published},
tppubtype = {article}
}

@article{Shah2018,
title = {Genome-wide association studies for corneal and refractive astigmatism in UK Biobank demonstrate a shared role for myopia susceptibility loci},
author = {RL Shah and JA Guggenheim and UK Biobank Eye and Vision Consortium},
url = {https://www.ncbi.nlm.nih.gov/pubmed/30306274},
year = {2018},
date = {2018-10-10},
journal = {Human Genetics},
abstract = {Previous studies have suggested that naturally occurring genetic variation contributes to the risk of astigmatism. The purpose of this investigation was to identify genetic markers associated with corneal and refractive astigmatism in a large-scale European ancestry cohort (UK Biobank) who underwent keratometry and autorefraction at an assessment centre. Genome-wide association studies for corneal and refractive astigmatism were performed in individuals of European ancestry (N = 86,335 and 88,005 respectively), with the mean corneal astigmatism or refractive astigmatism in fellow eyes analysed as a quantitative trait (dependent variable). Genetic correlation between the two traits was calculated using LD Score regression. Gene-based and gene-set tests were carried out using MAGMA. Single marker-based association tests for corneal astigmatism identified four genome-wide significant loci (P < 5 × 10-8) near the genes ZC3H11B (1q41), LINC00340 (6p22.3), HERC2/OCA2 (15q13.1) and NPLOC4/TSPAN10 (17q25.3). Three of these loci also demonstrated genome-wide significant association with refractive astigmatism: LINC00340, HERC2/OCA2 and NPLOC4/TSPAN10. The genetic correlation between corneal and refractive astigmatism was 0.85 (standard error = 0.068, P = 1.37 × 10-35). Here, we have undertaken the largest genome-wide association studies for corneal and refractive astigmatism to date and identified four novel loci for corneal astigmatism, two of which were also novel loci for refractive astigmatism. These loci have previously demonstrated association with axial length (ZC3H11B), myopia (NPLOC4), spherical equivalent refractive error (LINC00340) and eye colour (HERC2). The shared role of these novel candidate genes for astigmatism lends further support to the shared genetic susceptibility of myopia and astigmatism.},
keywords = {17351, eye, vision},
pubstate = {published},
tppubtype = {article}
}

@article{Welikala2017,
title = {Automated arteriole and venule classification using deep learning for retinal images from the UK Biobank cohort.},
author = {RA Welikala and P Foster and PH Whincup and AR Rudnicka and CG Owen and DP Strachan and SA Barman and UK Biobank Eye and Vision Consortium.},
url = {https://www.ncbi.nlm.nih.gov/pubmed/28917120},
year = {2017},
date = {2017-09-08},
journal = {Computers in Biology and Medicine},
abstract = {The morphometric characteristics of the retinal vasculature are associated with future risk of many systemic and vascular diseases. However, analysis of data from large population based studies is needed to help resolve uncertainties in some of these associations. This requires automated systems that extract quantitative measures of vessel morphology from large numbers of retinal images. Associations between retinal vessel morphology and disease precursors/outcomes may be similar or opposing for arterioles and venules. Therefore, the accurate detection of the vessel type is an important element in such automated systems. This paper presents a deep learning approach for the automatic classification of arterioles and venules across the entire retinal image, including vessels located at the optic disc. This comprises of a convolutional neural network whose architecture contains six learned layers: three convolutional and three fully-connected. Complex patterns are automatically learnt from the data, which avoids the use of hand crafted features. The method is developed and evaluated using 835,914 centreline pixels derived from 100 retinal images selected from the 135,867 retinal images obtained at the UK Biobank (large population-based cohort study of middle aged and older adults) baseline examination. This is a challenging dataset in respect to image quality and hence arteriole/venule classification is required to be highly robust. The method achieves a significant increase in accuracy of 8.1% when compared to the baseline method, resulting in an arteriole/venule classification accuracy of 86.97% (per pixel basis) over the entire retinal image.},
keywords = {computer, imaging, methodology, Retinal, vision},
pubstate = {published},
tppubtype = {article}
}

@article{Guggenheim2015,
title = {Role of Educational Exposure in the Association Between Myopia and Birth Order},
author = {MBBS PhD FRCOphth2 Jeremy A. Guggenheim PhD1; Cathy Williams},
url = {http://archopht.jamanetwork.com/article.aspx?articleid=2448580#Conclusions},
year = {2015},
date = {2015-10-08},
keywords = {15716, 375 eye, vision},
pubstate = {published},
tppubtype = {article}
}

@article{Cumberland2015b,
title = {Frequency and Distribution of Refractive Error in Adult Life: Methodology and Findings of the UK Biobank Study},
author = {Phillippa M Cumberland and Yanchun Bao and Pirro G Hysi and Paul J Foster and Christopher Hammond Jugnoo J S Rahi and UK Biobank Eyes & Vision Consortium},
url = {http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0139780},
year = {2015},
date = {2015-10-05},
journal = {PLOS one},
abstract = {Purpose

To report the methodology and findings of a large scale investigation of burden and distribution of refractive error, from a contemporary and ethnically diverse study of health and disease in adults, in the UK.
Methods

U K Biobank, a unique contemporary resource for the study of health and disease, recruited more than half a million people aged 40–69 years. A subsample of 107,452 subjects undertook an enhanced ophthalmic examination which provided autorefraction data (a measure of refractive error). Refractive error status was categorised using the mean spherical equivalent refraction measure. Information on socio-demographic factors (age, gender, ethnicity, educational qualifications and accommodation tenure) was reported at the time of recruitment by questionnaire and face-to-face interview.
Results

Fifty four percent of participants aged 40–69 years had refractive error. Specifically 27% had myopia (4% high myopia), which was more common amongst younger people, those of higher socio-economic status, higher educational attainment, or of White or Chinese ethnicity. The frequency of hypermetropia increased with age (7% at 40–44 years increasing to 46% at 65–69 years), was higher in women and its severity was associated with ethnicity (moderate or high hypermetropia at least 30% less likely in non-White ethnic groups compared to White).
Conclusions

Refractive error is a significant public health issue for the UK and this study provides contemporary data on adults for planning services, health economic modelling and monitoring of secular trends. Further investigation of risk factors is necessary to inform strategies for prevention. There is scope to do this through the planned longitudinal extension of the UK Biobank study.},
keywords = {669, vision},
pubstate = {published},
tppubtype = {article}
}

@conference{Cumberland2014,
title = {Visual health inequalities: findings from UK Biobank},
author = {Phillippa M Cumberland and Jugnoo S Rahi},
url = {http://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2814%2962153-X/fulltext},
year = {2014},
date = {2014-11-19},
journal = {The Lancet},
volume = {384},
pages = {S27},
abstract = {Background
Little is known about inequalities in eye health. Between 2009 and 2010, 117 908 UK Biobank participants (aged 40—69 years) undertook an ophthalmic assessment, which included distance visual acuity. UK Biobank was not designed to be a fully representative population sample so prevalence estimation is precluded. However, the size and diversity of the sample provide a unique opportunity for investigation of socioeconomic influences on visual health in UK adults.
Methods
Habitual (usual optical correction) distance acuity was measured with a standardised computer-based system. 112 314 participants were reliably assigned, on the basis of acuity in the better eye, into one of six categories spanning the spectrum of vision from bilateral normal vision (log of minimum angle of resolution [logMAR] 0·2 or better) to low-vision—blind (≤0·5, WHO taxonomy). Socioeconomic information included educational qualifications and Townsend Index. Multinomial and ordinal regression analyses were undertaken.
Findings
The frequency of normal bilateral vision decreased with age (age 40—49 years, 86% [21 934/25 645]; 50—59 years, 77% [27 482/35 786]; and 60—70 years, 72% [36 461/50 883]). Overall, risk of visual impairment across severity categories was associated with an increasing gradient of key demographic and socioeconomic variables, indicating deprivation. These patterns of visual health inequalities were not explained by risk of underlying eye disease. For example, compared with normal vision, socially significant visual impairment (SSVI), a mid-range category of visual impairment, was associated with increasing age (risk ratio 1·05, 95% CI 1·046—1·06), being female (1·09, 1·01—1·16), no educational qualifications (1·7, 1·4—1·9), a higher deprivation score (1·08, 1·07—1·09), and being part of any minority ethnic group (eg, Asian 2·5, 2·1—2·9). Participants unable to work or unemployed were at least 30% more likely to be in the SSVI category than were those with normal vision and, if employed, at least 9% more likely to have a lower status job.
Interpretation
There are consistent patterns of associations between visual impairment across the full spectrum including, importantly, people with mild impairment, and known health determinants as well as key social outcomes. To our knowledge, our study provides evidence for the first time that policies tackling health inequalities as well as initiatives to address inequalities in ophthalmological clinical settings have the potential to improve visual health outcomes.
Funding
This work was funded by the National Eye Research Centre. PMC is funded by the Ulverscroft Foundation and JSR receives part funding from the National Institute for Health Research (NIHR) Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and University College London Institute of Ophthalmology. The study was undertaken at University College London Institute of Child Health, which receives a proportion of its funding from the Department of Health's NIHR Biomedical Research Centres funding scheme.},
keywords = {669, vision},
pubstate = {published},
tppubtype = {conference}
}

@article{Rönnberg2014,
title = {The Effect of Functional Hearing Loss and Age on Long- and Short-term Visuospatial Memory: Evidence from the UK Biobank Resource},
author = {Jerker Rönnberg and Staffan Hygge and Gitte Keidser and Mary Rudner},
url = {http://journal.frontiersin.org/Journal/10.3389/fnagi.2014.00326/abstract},
year = {2014},
date = {2014-11-07},
journal = {Frontiers in Aging and Neuroscience},
volume = {6},
pages = {326},
abstract = {The UK Biobank offers cross-sectional epidemiological data collected on > 500 000 individuals in the UK between 40 and 70 years of age. Using the UK Biobank data, the aim of this study was to investigate the effects of functional hearing loss and hearing aid usage on visuospatial memory function. This selection of variables resulted in a sub-sample of 138 098 participants after discarding extreme values. A digit triplets functional hearing test was used to divide the participants into three groups: poor, insufficient and normal hearers. We found negative relationships between functional hearing loss and both visuospatial working memory (i.e., a card pair matching task) and visuospatial, episodic long-term memory (i.e., a prospective memory task), with the strongest association for episodic long-term memory. The use of hearing aids showed a small positive effect for working memory performance for the poor hearers, but did not have any influence on episodic long-term memory. Age also showed strong main effects for both memory tasks and interacted with gender and education for the long-term memory task. Broader theoretical implications based on a memory systems approach will be discussed and compared to theoretical alternatives.},
keywords = {3572, hearing, memory, vision},
pubstate = {published},
tppubtype = {article}
}

@article{Dawes2014b,
title = {Vision impairment and dual sensory problems in middle age.},
author = {P Dawes and C Dickinson and R Emsley and PN Bishop and KJ Cruickshanks and M Edmondson-Jones and A McCormack and H Fortnum and DR Moore and P Norman and K Munro},
url = {http://www.ncbi.nlm.nih.gov/pubmed/24888710},
year = {2014},
date = {2014-05-29},
journal = {Ophthalmic &amp; physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists).},
volume = {34},
number = {4},
pages = {479-88},
abstract = {PURPOSE:
Vision and hearing impairments are known to increase in middle age. In this study we describe the prevalence of vision impairment and dual sensory impairment in UK adults aged 40-69 years in a very large and recently ascertained data set. The associations between vision impairment, age, sex, socioeconomic status, and ethnicity are reported.
METHODS: This research was conducted using the UK Biobank Resource, with subsets of UK Biobank data analysed with respect to self-report of eye problems and glasses use. Better-eye visual acuity with habitually worn refractive correction was assessed with a logMAR chart (n = 116,682). Better-ear speech reception threshold was measured with an adaptive speech in noise test, the Digit Triplet Test (n = 164,770). Prevalence estimates were weighted with respect to UK 2001 Census data.
RESULTS:
Prevalence of mild visual impairment (VA >0.1 logMAR (6/7.5, 20/25) and ≥0.48 (6/18, 20/60)) and low vision (VA >0.48 (6/18, 20/60) and ≥1.3 (6/120, 20/400)) was estimated at 13.1% (95% CI 12.9-13.4) and 0.8% (95% CI 0.7-0.9), respectively. Use of glasses was 88.0% (95% CI 87.9-88.1). The prevalence of dual sensory impairment was 3.1% (95% CI 3.0-3.2) and there was a nine-fold increase in the prevalence of dual sensory problems between the youngest and oldest age groups. Older adults, those from low socioeconomic and ethnic minority backgrounds were most at risk for vision problems.
CONCLUSIONS:
Mild vision impairment is common in middle aged UK adults, despite widespread use of spectacles. Increased likelihood of vision impairment with older age and with ethnic minorities is of concern given ageing and more ethnically diverse populations. Possible barriers to optometric care for those from low socioeconomic and ethnic minority backgrounds may require attention. A higher than expected prevalence of dual impairment suggests that hearing and vision problems share common causes. Optometrists should consider screening for hearing problems, particularly among older adults.},
keywords = {166, eyesight, vision},
pubstate = {published},
tppubtype = {article}
}