@article{whalleyhc2016,
title = {Dissection of major depressive disorder using polygenic risk scores for schizophrenia in two independent cohorts},
author = {Hall Clarke Fernandez-Pujals Gibson Wigmore Hafferty Hagenaars Davies Campbell Hayward Lawrie Porteous Deary McIntosh M J L S T K A M J E J S P G A C S M D J I J A M Whalley H. C. Adams},
url = {https://www.ncbi.nlm.nih.gov/pubmed/27801894},
year = {2016},
date = {2016-11-02},
journal = {Transl Psychiatry},
abstract = {Major depressive disorder (MDD) is known for its substantial clinical and suspected causal heterogeneity. It is characterized by low mood, psychomotor slowing and increased levels of the personality trait neuroticism; factors also associated with schizophrenia (SCZ). It is possible that some cases of MDD may have a substantial genetic loading for SCZ. The presence of SCZ-like MDD subgroups would be indicated by an interaction between MDD status and polygenic risk of SCZ on cognitive, personality and mood measures. Here, we hypothesized that higher SCZ polygenic risk would define larger MDD case-control differences in cognitive ability, and smaller differences in distress and neuroticism. Polygenic risk scores (PRSs) for SCZ and their association with cognitive variables, neuroticism, mood and psychological distress were estimated in a large population-based cohort (Generation Scotland: Scottish Family Health Study, GS:SFHS). The individuals were divided into those with, and without, depression (n=2587 and n=16 764, respectively) to test for the interactions between MDD status and schizophrenia risk. Replication was sought in UK Biobank (UKB; n=6049 and n=27 476 cases and controls, respectively). In both the cohorts, we found significant interactions between SCZ-PRS and MDD status for measures of psychological distress (betaGS=-0.04},
keywords = {12580, Depressive disorder, genetics, schizophrenia},
pubstate = {published},
tppubtype = {article}
}